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Sunday Poster Session
Category: Esophagus
Ikuo Hirano, MD
Northwestern University Feinberg School of Medicine
Chicago, IL, United States
Table. Correlations between esophageal intraepithelial eosinophil count (eos/hpf) and EREFS total score, inflammation and remodeling subscores, and individual components scores in patients with EoE receiving placebo in the phase 2 POC study and part A of the phase 3 LIBERTY TREET study. | ||||||
Pearson correlation coefficients (ρ) | EoE Phase 2 POC study (N = 24) | EoE Phase 3 TREET Part A study (N = 39) | ||||
Baseline (n = 24) | EOT Week 12 (n = 22) | Change from BL to EOT (n = 22) | Baseline (n = 39) | EOT Week 24 (n = 27) | Change from BL to EOT (n = 27) | |
Eos/hpf x EREFS totala ρ |
|
0.2007 |
0.1249 |
0.0001 |
0.0130 |
0.8362 |
Eos/hpf x EREFS inflammation subscoreb ρ |
0.0850 |
0.0207 |
0.0331 |
0.0002 |
0.0626 |
0.5790 |
Eos/hpf x EREFS edema component ρ |
0.1013 |
0.1088 |
0.0576 |
0.0710 |
0.7555 |
0.9567 |
Eos/hpf x EREFS exudates component ρ |
0.1453 |
0.0121 |
0.0390 |
0.0020 |
0.0387 |
0.1758 |
Eos/hpf x EREFS furrows component ρ |
0.3576 |
0.4575 |
0.2829 |
0.0163 |
|
|
Eos/hpf x EREFS remodeling subscorec ρ |
0.4353 |
0.9136 |
0.9428 |
0.6634 |
0.2542 |
0.5297 |
Eos/hpf x EREFS rings component ρ |
0.6687 |
0.7958 |
0.4758 |
0.7730 |
0.2289 |
0.4841 |
Eos/hpf x EREFS stricture component ρ |
0.2986 |
0.4695 |
0.0680 |
0.5265 |
0.8818 |
0.8794 |
a EREFS total score is the sum of all component scores for proximal and distal regions.
b EREFS inflammation subscore is the sum of edema, exudates, and furrows for proximal and distal regions.
c EREFS remodeling subscore is the sum of rings and strictures for proximal and distal regions.
Cohen’s rule of thumb denotes a correlation coefficient of 0.10 as weak relationship, 0.3 as moderate relationship, and 0.5 as strong relationship (Cohen J.,1988, Statistical Power Analysis for the Behavioral Sciences, 2nd ed. Hillsdale, NJ: Erlbaum).
Analyses were performed post hoc and P values are nominal.
BL, baseline; EREFS, Endoscopic Reference Score; Eos, eosinophils; EOT, end of treatment; hpf, high-powered field.