P1052 - Does Sex Influence Outcomes in Patients Hospitalized With Acute Pancreatitis? A National Inpatient Sampling Database Analysis

Usman Tariq, MD¹, Azeem Malik, MD², Bandhul Hans, MD¹, Rahul Karna, MD¹, Heitham Abdul-Baki, MD^1
1Allegheny Health Network, Pittsburgh, PA; ²The Ohio State University Wexner Medical Center, Columbus, OH

Introduction: Pancreatitis is the most common gastrointestinal diagnosis warranting inpatient admissions in the United States. We sought to determine the impact of gender on inpatient complications using a longitudinal hospital care database.

Methods: The National Inpatient Sampling database (2010-2015 q3) was queried to identify patients who underwent hospitalization for a primary diagnosis of acute pancreatitis. ICD-9 codes were used to identify inpatient complications which included urinary tract infections (UTIs), pneumonia/respiratory complications, acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), acute myocardial infarction (MI), stroke, shock, and acute kidney injury (AKI). Multivariate cox regression analyses were used to determine whether gender was associated with a difference in the rate of inpatient complications.

Results: A total of 1,378,496 patients were admitted for acute pancreatitis between 2010-September 2015, of which 655,872 were female (47.5%). In regards to inpatient complications, female patients were less likely to develop pneumonia (OR 0.79 [0.76-0.81]; p< 0.001), respiratory complications (OR 0.74 [0.72-0.75]; p< 0.001), ARDS (OR 0.71 [0.70-0.73]; p< 0.001), SIRS (OR 0.72 [0.70-0.74]; p< 0.001), thromboembolic events (OR 0.73 [0.69-0.78]; < 0.001), acute MI (OR 0.80 [0.76-0.85], p< 0.001) and AKI (OR 0.66 [0.65-0.68]; p< 0.001). Compared to men, females were more likely to develop UTIs (OR 4.13 [4.06-2.30]; p< 0.001) and stroke(s) (OR 1.02 [0.91-1.14]; p< 0.001) during inpatient stay (Table 1).

Discussion: Females admitted for acute pancreatitis have a smaller disposition for a wide array of inpatient complications compared to their male counterparts. Further studies are required to delineate the causality between gender and inpatient complications in this study population.

Complications	Males (%)	Females (%)	Adjusted OR [95% CI]	P-value
UTI	19015 (2.6%)	67110 (10.2%)	4.13 [4.06-2.30]	< 0.001
ARDS	17024 (2.4%)	11702 (1.8%)	0.71 [0.70-0.73]	< 0.001
SIRS	12410 (1.7%)	8261 (1.3%)	0.72 [0.70-0.74]	< 0.001
Thromboembolic events	2990 (0.4%)	2519 (0.4%)	0.73 [0.69-0.78]	< 0.001
Stroke	704 (0.1%)	659 (0.1%)	1.02 [0.91-1.14]	< 0.001
Pneumonia	22127 (3.1%)	17471 (2.7%)	0.79 [0.76-0.81]	< 0.001
Respiratory complications	20273 (2.8%)	14689 (2.2%)	0.74 [0.72-0.75]	< 0.001
Acute MI	2987 (0.4%)	2641 (0.4%)	0.80 [0.76-0.85]	< 0.001
Sepsis	13618 (1.9%)	8985 (1.4%)	0.63 [0.61-0.65]	< 0.001
Shock	913 (0.1%)	727 (0.1%)	0.81 [0.73-0.90]	< 0.001
AKI	69417 (9.6%)	48483 (7.4%)	0.66 [0.65-0.68]	< 0.001

Table: Table 1: Gender-Based Disparities in Inpatient Complications Amongst Patients with Acute Pancreatitis. UTI: Urinary tract infection; ARDS: Acute respiratory distress syndrome; SIRS: Systemic inflammatory response syndrome; MI: Myocardial infarction; AKI: Acute kidney injury


Disclosures:
Usman Tariq indicated no relevant financial relationships.
Azeem Malik indicated no relevant financial relationships.
Bandhul Hans indicated no relevant financial relationships.
Rahul Karna indicated no relevant financial relationships.
Heitham Abdul-Baki indicated no relevant financial relationships.


Usman Tariq, MD¹, Azeem Malik, MD², Bandhul Hans, MD¹, Rahul Karna, MD¹, Heitham Abdul-Baki, MD¹. P1052 - Does Sex Influence Outcomes in Patients Hospitalized With Acute Pancreatitis? A National Inpatient Sampling Database Analysis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.