P1185 - Risk Factors for Location of Colonic Diverticulosis in an Aging Population - A Retrospective Study

Hammad Liaquat, MD¹, Hussam Tayel, MD¹, Farah Harmouch, MD¹, Brian Kim, DO², Berhanu Geme, MD³, Kimberly Chaput, DO^2
1St. Luke's University Health Network, Bethlehem, PA; ²St. Luke's University Health Network, Fountain Hill, PA; ³St. Luke's University Hospital, Bethlehem, PA

Introduction: Diverticulosis has been increasing in prevalence overtime in Western and Asian countries. Left sided disease is more common in Western and developed countries while right sided diverticulosis is seen more often in Asian and developing countries. Little is known about pan-diverticulosis and its risk factors. Our study aims to reveal risk factors that contribute to location of the disease within the colon.

Methods: We conducted a retrospective chart review to identify patients over the age of 75 who underwent a colonoscopy between 2012 and 2019 within our health network. We collected data on patient demographics, comorbidities, and colonoscopy findings. All statistical analyses were conducted in IBM SPSS Version 26 to analyze our data.

Results: A total of 908 patients were included in our sample initially, however 5 patients with solitary right sided diverticulosis were excluded from the study as the population size was too small in comparison. Median age was 78. Most of the patients were Caucasian (91.4%) and female (57.1%) with a history of hypertension (83.3%) and left sided diverticulosis (69.4%). A significant proportion of patients had constipation (35.2%), ASA ≥3 (38.5%), and IFG (Impaired fasting glucose) (34.7%). Higher proportion of patients with pan-diverticulosis had ASA ≥3, metabolic syndrome, hypertriglyceridemia, hypertension, and hypothyroidism, while obesity was more prevalent in patients with left sided diverticulosis only.

Discussion: In Asian countries, right sided colon diverticulosis pre-dominates and studies are inconclusive about role of dietary intake, lifestyle, racial or genetic predisposition. In the US population, diverticulosis mostly occurs on the left side and is thought to be due to lifestyle factors. Risk factors for pan-diverticulosis continue to evolve. Our study revealed that higher prevalence of metabolic syndrome and most of its constituents are associated with an increased risk for pan-diverticulosis. These results should be investigated by larger studies along with further analysis of risk factors.



Disclosures:


Hammad Liaquat, MD¹, Hussam Tayel, MD¹, Farah Harmouch, MD¹, Brian Kim, DO², Berhanu Geme, MD³, Kimberly Chaput, DO². P1185 - Risk Factors for Location of Colonic Diverticulosis in an Aging Population - A Retrospective Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.