P1198 - Understanding Regional Trends and Discrepancies of Appendiceal Cancer in the U.S.

Anas Raed, MD¹, Amol Sharma, MD¹, Shreyu Umapathy, ², John Erikson Yap, MD³, Humberto Sifuentes, MD⁴, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG^5
1Augusta University, Augusta, GA; ²August Georg University, Augusta, GA; ³Medical College of Georgia at Augusta University, Augusta, GA; ⁴Medical College of Georgia, Augusta, GA; ⁵AUMC, Augusta, GA

Introduction: Appendiceal cancer (AC) is an uncommon malignancy and its epidemiology and the regional distribution of this disease in the USA is unknown. Our aim was to determine the incidence rate variations of AC by geographic location, specifically by regions and the states.

Methods: Data was extracted from the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology and End Results (SEER) for the period 2001-2016. Age-adjusted incidence and annual percent change (APC) were calculated in a step-wise manner to examine the trends among each of the four US regions, followed by 13 individual SEER-reported states. SEER Stat software was used to analyze the data.

Results: The incidence rates of AC in population ≥50 & < 50 years have significantly increased in all the US regions, with the highest rates of increased incidence in the West among population younger than 50 years with APC 12.8 (CI: 9.3, 16.5) (table 1). When examining the incidence rates of AC by states, the rates have increased significantly among the population ≥50 & < 50 in all 12 SEER-reported states except Alaska. The highest increase was noted in Kentucky with APC16.5 (CI: 12.3, 20.8), and particularly in the population < 50 years with APC 16.5 (CI: 12.3, 20.8) (table 2).

Discussion: This study clearly demonstrates an alarming increase in the incidence of AC nationwide and provides an update of AC incidence rates by geographic location. Exploring risk factors, especially in state of Kentucky is critical to address the progression of this deadly disease.


Disclosures:


Anas Raed, MD¹, Amol Sharma, MD¹, Shreyu Umapathy, ², John Erikson Yap, MD³, Humberto Sifuentes, MD⁴, Subbaramia Sridhar, MBBS, MPH, FRCP, FRCPC, FACG⁵. P1198 - Understanding Regional Trends and Discrepancies of Appendiceal Cancer in the U.S., ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.