P2104 - Outcomes of Patients with Acute Pancreatitis Found to Have a Pancreatic Mass vs Those With Only Acute Pancreatitis – A Population Based Study (2012-2018)

Neethi R. Dasu, DO¹, Yaser Khalid, DO², Herman Suga, DO³, C Jonathan Foster, DO⁴, Donald J. McMahon, DO^5
1Rowan University School of Osteopathic Medicine, Jefferson Health NJ, Voorhees Township, NJ; ²Wright Center for Graduate Medical Education, Davie, FL; ³Rowan University School of Osteopathic Medicine, Jefferson Health NJ, Laurel Springs, NJ; ⁴Thomas Jefferson University Hospital, Cherry HIll, NJ; ⁵Thomas Jefferson University Hospital, Turnersville, NJ

Introduction: Acute pancreatitis (AP) is a condition that confers an increased risk for pancreatic malignancy compared to the age- and the sex-matched general population. However, to our knowledge, there is no study that evaluates the effect of sex, race, insurance status, hospital length of stay (LOS), mortality, and total hospital charges for patients with AP who subsequently are diagnosed with a pancreatic mass compared to patients with who only present with Acute Pancreatitis. The aim of this study was to identify key risk factors in a national population cohort (in the USA) admitted to hospitals between the years 2012 through 2018.



Methods: All patients aged 18 years and above in this patient population were identified from the US Nationwide Inpatient Sample (NIS). Multivariate regression analysis was used to estimate the odds ratios of in-hospital mortality, the average length of hospital stay, and hospital charges, after adjusting for age, gender, race, primary insurance payer status, hospital type and size (number of beds), hospital region, hospital teaching status, and other demographic characteristics.

Results: Our study identified approximately 113,685 patients who had been admitted with AP and found to have a pancreatic mass as well as patients with AP without a pancreatic mass. Of these patients, 8,828 were admitted with AP and subsequently found to have a pancreatic mass versus 104,857 with only AP. The analysis revealed that the average age was 61.24. Immediate mortality [OR 0.36 (0.31-0.42), p< 0.0001 ] for patients with AP and a pancreatic mass was decreased, however length of stay (LOS) was increased (OR 2.01 (2.0-2.02), p< 0.0001 ]. Independent positive predictors of mortality were the presence of ascites [ OR 2.79 (1.04-7.47), p< 0.042 ], variceal Bleeding [5.22 (1.89-14.40), p< 0.001], and acute liver failure (ALF) [6.03 (1.22029.63), p< 0.027].

Discussion: Interestingly, patients with both AP and a pancreatic mass had decreased mortality compared to patients with only AP. Furthermore, the presence of ascites, variceal bleeding, and ALF contributed to an increased LOS for these patients. Patients with AP and a pancreatic mass are theoretically at very high risk for complications, but our study shows that this patient population actually had decreased mortality. Further studies are needed to examine this relationship.


Disclosures:


Neethi R. Dasu, DO¹, Yaser Khalid, DO², Herman Suga, DO³, C Jonathan Foster, DO⁴, Donald J. McMahon, DO⁵. P2104 - Outcomes of Patients with Acute Pancreatitis Found to Have a Pancreatic Mass vs Those With Only Acute Pancreatitis – A Population Based Study (2012-2018), ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.