United Health Services Johnson City, NY, United States
M'hamed Turki, MD1, Saif Bella, MD2, Alexsaundra Zywicki, 3, Patrick Castle, 4, Amine Hila, MD2 1United Health Services, Johnson City, NY; 2United Health Services, Binghamton, NY; 3SUNY Upstate Medical University, Johnson City, NY; 4State University of New York Upstate Medical Center, Johnson City, NY
Introduction: Obesity is associated with low-grade chronic inflammation, which has been linked to perioperative complications. Body mass index (BMI) has long been a traditional marker of obesity. Leukocyte counts and platelet counts, and C-reactive protein (CRP) are readily available test markers of inflammation. It has not been well studied whether these blood indices correlate with obesity and postoperative adverse outcomes.
This study aims to examine the relationship between preoperative blood indices such as leukocyte counts, platelet counts, albumin, and CRP as markers of inflammation as well as hospital length of stay and obesity defined by BMI in patients undergoing elective hiatal hernia repair.
Methods: This cross-sectional study was performed on 212 patients who underwent elective laparoscopic hiatal hernia(HH) repair and Nissen Fundoplication procedures for large HH and refractory gastroesophageal reflux disease, which was performed from January 2010 to February 2020. Patients were categorized into different groups according to their BMI. Obesity was defined by a BMI ≥ of 30 kg/m2. Preoperative blood indices and length of stay data were gathered and analyzed.
Results: Preliminary data of 212 patients were collected and analyzed. One hundred twelve were obese. Mean age of 60 years old. See table and graph.
Discussion: Our study demonstrated that there was an association between CRP and obesity defined by BMI. There was no other association between other markers of inflammation and obesity in this studied population. The study's finding suggests that overall obesity is associated with a higher acute inflammatory response,consistent with previous studies. Blood indices, including Leukocyte count, platelet counts, Albumin, and Creatinine, had no significant association with obesity defined by BMI. However, higher BMI is independently associated with higher CRP and prolonged hospital stay in patients undergoing elective laparoscopic HH repair and Nissen Fundoplication procedures for large hiatal hernia and refractory GERD.
Figure: Box-plot graph depicting the relationship between obesity ,and CRP and length of hospital stay
BMI >30
BMI< 30
P-value (Mann Whitney test)
Age
59.97±14.3
60.7±17.3
Female (%)
74
65
WBC (mean±SD)
7.8±3.5
7.3±3
Platelet (mean±SD)
255.7±88
464±12
Creatinine (mean±SD)
0.9±0.5
0.8±0.2
Albumin mean±SD)
3.9 ± 0.4
3.8 ± 0.5
CRP ( mean±SD)
4.5±2.3
1.4±1.1
< 0.0001
Median hospital length of stay (days)
4
2
0.0008
Table: Table summurizing study population and results
Disclosures:
M''hamed Turki indicated no relevant financial relationships.
Saif Bella indicated no relevant financial relationships.
Alexsaundra Zywicki indicated no relevant financial relationships.
Patrick Castle indicated no relevant financial relationships.
Amine Hila indicated no relevant financial relationships.
M'hamed Turki, MD1, Saif Bella, MD2, Alexsaundra Zywicki, 3, Patrick Castle, 4, Amine Hila, MD2. P0868 - Relationship Between Preoperative Blood Indices and Obesity in Patient Undergoing Hiatal Hernia Repair, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.
