Loyola University Medical Center Maywood, IL, United States
Adnan Malik, MD1, Muhammad Malik, MBBS, MRCP2, Mahum Nadeem, MD3, Waseem Amjad, MD4 1Loyola University Medical Center, Maywood, IL; 2Airedale General Hospital, West Yorkshire, England, United Kingdom; 3University of Oklahoma Health Sciences Center, Oklahoma City, OK; 4Albany Medical Center, Albany, NY
Introduction: Gastric adenocarcinoma (GAC) is a deadly tumor. Postoperative complications, including infections, worsens its prognosis and may affect overall survival. A little is known about perioperative complications and modifiable and non modifiable risk factor. Early detection and treatment of these risk factors may affect overall survival and mortality.
Methods: We extracted GAC patient's data from the Surveillance, Epidemiology, and End Results (SEER) database and analysed using pearson’s chi-square, cox regression, kaplan-Meier, and binary regression methods in SPSS.
Results: At the time of analysis 59,580 GAC patients were identified of which 854 were dead due to infection. Overall, mean survival in months was better for younger patients, age < 50 years vs ≥ 50 years (60.452 vs 56.75), and in females vs males (65.239 vs 53.247). The multivariate analysis showed that the risk of infectious mortality was higher in patients with age ≥ 50 years (HR, 3.137; 95% CI, 2.178-4.517), not treated with chemotherapy (HR, 1.669; 95% CI, 1.356-2.056), or surgery (HR, 1.412; 95% CI, 1.132-1.761) and un-staged patients (HR, 1.699; 95% CI, 1.278-2.258). In contrast, the mortality risk was lower in females (HR, 0.658; 95% CI, 0.561-0.773) and married patients (HR, 0.627; 95% CI, 0.506-0.778). The probability of infection was higher in older patients (OR of 2.094 in ≥ 50 years), other races in comparison to white and back (OR, 1.226), lesser curvature, NOS as a primary site (OR, 1.325), and patients not receiving chemotherapy (OR, 1.258).
Discussion: Older, unmarried males with GAC who are not treated with chemotherapy or surgery are at a higher risk for infection-caused mortality and should be given special attention while receiving treatment.
Adnan Malik indicated no relevant financial relationships.
Muhammad Malik indicated no relevant financial relationships.
Mahum Nadeem indicated no relevant financial relationships.
Waseem Amjad indicated no relevant financial relationships.
Adnan Malik, MD1, Muhammad Malik, MBBS, MRCP2, Mahum Nadeem, MD3, Waseem Amjad, MD4. P2026 - The Risk of Infection-Caused Mortality in Gastric Adenocarcinoma: A Population-Based Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.