P2026 - The Risk of Infection-Caused Mortality in Gastric Adenocarcinoma: A Population-Based Study

Adnan Malik, MD¹, Muhammad Malik, MBBS, MRCP², Mahum Nadeem, MD³, Waseem Amjad, MD^4
1Loyola University Medical Center, Maywood, IL; ²Airedale General Hospital, West Yorkshire, England, United Kingdom; ³University of Oklahoma Health Sciences Center, Oklahoma City, OK; ⁴Albany Medical Center, Albany, NY

Introduction: Gastric adenocarcinoma (GAC) is a deadly tumor. Postoperative complications, including infections, worsens its prognosis and may affect overall survival. A little is known about perioperative complications and modifiable and non modifiable risk factor. Early detection and treatment of these risk factors may affect overall survival and mortality.

Methods: We extracted GAC patient's data from the Surveillance, Epidemiology, and End Results (SEER) database and analysed using pearson’s chi-square, cox regression, kaplan-Meier, and binary regression methods in SPSS.

Results: At the time of analysis 59,580 GAC patients were identified of which 854 were dead due to infection. Overall, mean survival in months was better for younger patients, age < 50 years vs ≥ 50 years (60.452 vs 56.75), and in females vs males (65.239 vs 53.247). The multivariate analysis showed that the risk of infectious mortality was higher in patients with age ≥ 50 years (HR, 3.137; 95% CI, 2.178-4.517), not treated with chemotherapy (HR, 1.669; 95% CI, 1.356-2.056), or surgery (HR, 1.412; 95% CI, 1.132-1.761) and un-staged patients (HR, 1.699; 95% CI, 1.278-2.258). In contrast, the mortality risk was lower in females (HR, 0.658; 95% CI, 0.561-0.773) and married patients (HR, 0.627; 95% CI, 0.506-0.778). The probability of infection was higher in older patients (OR of 2.094 in ≥ 50 years), other races in comparison to white and back (OR, 1.226), lesser curvature, NOS as a primary site (OR, 1.325), and patients not receiving chemotherapy (OR, 1.258).

Discussion: Older, unmarried males with GAC who are not treated with chemotherapy or surgery are at a higher risk for infection-caused mortality and should be given special attention while receiving treatment.


Disclosures:


Adnan Malik, MD¹, Muhammad Malik, MBBS, MRCP², Mahum Nadeem, MD³, Waseem Amjad, MD⁴. P2026 - The Risk of Infection-Caused Mortality in Gastric Adenocarcinoma: A Population-Based Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.