1667 - **Change in characteristics of community-onset ciprofloxacin-resistant E. coli isolates causing community-acquired acute pyelonephritis in South Korea.**

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Presenting Author(s)

BK

Bongyoung Kim

Associate Professor
Department of Internal Medicine, Hanyang University College of Medicine
Seongdong-gu, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Co-Author(s)

KK

Ki Tae Kwon

Professor
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
Daegu, Taegu-jikhalsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
SR

Seong-yeol Ryu

Dr
Keimyung University Dongsan Medical Center
Daegu, Taegu-jikhalsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
SW

Seong-Heon Wie

Professor
Division of Infectious Diseases, Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Kyonggi-do, Kyonggi-do, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
HJ

Hyun-uk Jo

Assistant professor
Department of Urology, School of Medicine, Eulji University, Daejeon, Korea
Daejeon, Taejon-jikhalsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
JK

Jieun Kim

Associate professor
Department of Internal medicine, Hanyang University College of Medicine
Seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
Se Yoon Park

Assistant professor
fectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea
seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
KH

Kyung-Wook Hong

Assistant professor
Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea
Jinju, Kyongsang-namdo, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
HK

Hye In Kim

Dr
Daegu Fatima Hospital
Daegu, Taegu-jikhalsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
HK

Hyun ah Kim

Associate professor
Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea
Daegu, Taegu-jikhalsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MK

Mi-Hee Kim

Infectious Diseases Fellow
Division of Infectious Diseases, Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
Kyonggi-do, Kyonggi-do, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MB

Mi-Hyun Bae

Assistant professor
Department of laboratory medicine, Hanyang University College of Medicine
Seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
YS

Yong-Hak Sohn

Laboratory medicine specialist
Seegene Medical Foundation, Seoul, Korea
Seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
JK

Jieun Kim

Assistant professor
Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
Seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
YL

Yangsoon Lee

Associate professor
Department of laboratory medicine, Hanyang University College of Medicine
Seoul, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
HP

Hyunjoo Pai

Professor
Department of Internal Medicine, Hanyang University College of Medicine
Seongdong-gu, Seoul-t'ukpyolsi, Republic of Korea
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Background: The aim of this study was to examine the change in characteristics of community-onset ciprofloxacin-resistant (CIP-R) E. coli isolates causing community-acquired acute pyelonephritis (CA-APN) in South Korea between 2010-2011 and 2017-2018.

Methods: E. coli samples isolated from the blood or urine were collected from patients with CA-APN aged 19 years and more who were admitted to 8 Korean hospitals from September 2017 to August 2018, prospectively. One isolate was collected from each patient. Phylogenetic typing, multilocus sequence typing (MLST), and molecular characterization of β-lactamase resistance and plasmid-mediated quinolone resistance (PMQR) determinants were performed. The data were compared with those from the previous study with same design in 2010-2011.

Results: A total of 346 and 300 isolates were collected during 2017-2018 and 2010-2011, respectively. Among them, 76 (22.0%) and 77 (25.7%) were CIP-R isolates. Significantly higher antimicrobial resistance against ampicillin (75.7% vs. 100%, P < 0.001) and cefotaxime (23.9% vs. 77.9%, P < 0.001) were observed for isolates in 2017-2018 compared to those in 2010-2011. The proportion of phylogenic group B2 had increased significantly (44.7% vs. 79.2%, P < 0.001). As for MLST, the proportion of ST131 (27.6% vs. 66.2%, P < 0.001) had increased while that of ST393 (18.4% vs. 3.9%, P =0.004) had decreased significantly. Higher proportion of CIP-R E. coli isolates in 2017-2018 had extended-spectrum β-lactamase (ESBL)/plasmid-mediated AmpC β-lactamase (PABL) (23.7% vs. 79.2%, P < 0.001) and PMQR determinant (11.8% vs. 40.8%, P < 0.001) compared to those in 2010-2011.Phlogenetic tree

Analyzed by SplitsTree

Conclusion: Among uropathogenic CIP-R E. coli isolates in South Korea, ST131 predominance had become more prominent and the proportion of containing ESBL/PABL and/or PMQR determinants had increased.

1667 - Change in characteristics of community-onset ciprofloxacin-resistant E. coli isolates causing community-acquired acute pyelonephritis in South Korea.

Presenting Author(s)

Co-Author(s)

1667 - **Change in characteristics of community-onset ciprofloxacin-resistant E. coli isolates causing community-acquired acute pyelonephritis in South Korea.**