832 - Assessment of Risk Factors Associated with Wide-resistance Gram-negative Bacteria Infections

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Presenting Author(s)

HL

Henry Pablo Lopes Campos e Reis

Pharmacist
Hospital Universitário Walter Cantídio
fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Co-Author(s)

AF

Ana Beatriz Ferreira Rodrigues

Student
Universidade Federal do Ceará
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
JC

Julio César Castro Silva

Student
Universidade Federal do Ceará
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
LP

Lia Pinheiro de Lima

Student
Universidade Federal do Ceará
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
TL

Talita Lima Quinaher

Student
Universidade Federal do Ceará
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
TC

Thaynara Carvalho de Freitas

Pharmacist resident
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
CP

Carla Mônica Porto Pereira

Pharmacist intern
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
BQ

Breno Queiroz de Araujo

Pharmacist resident
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AB

Abel Brasil Ramos Da Silva

Statistical
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
GP

Germana Perdigão Amaral

Nurse
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
GM

Geovania Maciel de Souza

Nurse
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
LC

Luciana Vladia Carvalhedo Fragoso

Nurse
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
ES

Evelyne Santana Girão

ID Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
LB

Licia Borges Pontes

ID Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AA

Arnaldo Aires Peixoto Junior

Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
VN

Vitor Nogueira Araujo

Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
FB

Fernando Barroso Duarte

Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
KS

Karine Sampaio Nunes Barroso

Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
JN

Jorge Luiz Nobre Rodrigues

ID Physician
Hospital Universitário Walter Cantídio
Fortaleza, Ceara, Brazil
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Background: Enterobacteria and multidrug-resistant non-fermenting Gram-negative bacilli present a challenge in the management of invasive infections, leading to mortality rates due to their limited therapeutic arsenal. The objective of this work was to analyze risk factors that may be associated with these infections, for a better situational mapping and assertive decision-making in a university hospital in Brazil.

Methods: The study was conducted between January and September 2019, with 167 patients in contact isolation at a university hospital in Brazil. Potential outcome-related variables for wide-resistance Gram-negative bacteria (BGN) infections were evaluated. Risk factors were identified from univariate statistical analysis using Fisher's test.

Results: 51 (30.5%) out of 167 patients in contact isolation evolved with wide-resistance BGN infection. Risk factors in univariate analysis were age, hospital unit and previous use of invasive devices. Patients aged up to 59 years were more likely to progress to infection than those aged over 60 years (p 0.0274, OR 2.2, 95% CI 1.1-4.5). Those admitted to the oncohematology (p < 0.001, OR 32.5, Cl 9.1-116.3) and intensive care unit (p < 0.001, OR 28.0, Cl 3.5-225.9) units were more likely to develop this type of infection. The least likely were those admitted to a kidney transplant unit (p 0.0034, OR 15.33, Cl 1.8-131.0). Prior use of mechanical ventilation (p 0.0058, OR 12.2, Cl 2.0-76.1) and delayed bladder catheter (p 0.0266, OR 5.0, Cl 1.2-20.1) in patients with respiratory and urinary tract infection, respectively, were also reported as risk factors related to these infections. The gender of the patients was not significant for the study.

Conclusion: This study determined that variables such as age, hospitalization unit, use of mechanical ventilation and delayed bladder catheter could be considered important risk factors in triggering the infectious process by wide-resistant gram-negative bacteria. Thus, the analysis of these factors becomes a great foundation to prevent the development of multiresistant pathogens through prevention strategies, prophylaxis management and more targeted empirical therapies.