O-38 - Transplant and Immunocompromosed Hosts

Co-Author(s)

• BA

  Brenda Akoto, n/a

  Research Technician
  Fred Hutch
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• MB

  Merav Bar, MD

  Associate Professor / Associate Professor, Division of Medical Oncology
  Clinical Research Division / Medical Oncology Division
  Fred Hutchinson Cancer Research Center / Department of Medicine University of Washington
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• AB

  Aart Beeker, MD PhD

  Attending Hemato-oncologist
  Medicine
  Spaarne Gasthuis
  Hoofddorp, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• 

  Michael Boeckh, MD PhD

  Member
  Internal Medicine
  Fred Hutchinson Cancer Research Center
  Seattle, Washington

  Disclosure: AlloVir (Consultant)EvrysBio (Advisor or Review Panel member, Other Financial or Material Support, share options)Gilead (Consultant, Grant/Research Support)GSK (Consultant)Helocyte (Advisor or Review Panel member, Shareholder)Lophius (Grant/Research Support)Merck (Consultant, Grant/Research Support)SymBio (Consultant)VirBio (Consultant, Grant/Research Support)
• JB

  Jim Boonyaratanakornkit, MD PhD

  Dr.
  Fred Hutchinson Cancer Research Center
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• AB

  Andries Budding, MD PhD

  Medical Microbiologist
  Medical Microbiology
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• AC

  Aastha Chandak, PhD

  Senior Manager, Head US Statistics
  Certara
  New York, New York

  Disclosure: AlloVir (Independent Contractor)
• NC

  Nelson Chao, MD

  Dr
  Duke
  Durham, North Carolina

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JC

  Jasmine Chung Shimin, MBBS (Hons)(Australia), MRCP (UK)

  Dr
  Department of Infectious Diseases
  Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JC

  Juleon Coenen, MD PhD

  Attending Hematologist
  Hematology
  Isala hospital
  Zwolle, Overijssel, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• 

  Michael Dagher, MD

  Research Scholar
  Division of Infectious Diseases, Department of Internal Medicine
  Duke University Medical Center
  Durham, North Carolina

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• Ad

  Arne de Kreuk, MD PhD

  Attending Hematologist
  Medicine, Division of Hematology
  Onze Lieve Vrouwe Gasthuis
  London, England, United Kingdom

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• SD

  Stephen De Rosa, MD

  Associate Member
  Vaccine and Infectious Diseases Division
  Fred Hutch
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• ED

  Elizabeth Duke, MD

  Acting Assistant Professor
  Fred Hutch
  Seattle, Washington

  Disclosure: Merck (Grant/Research Support)
• BE

  Bradley Edmison, BS

  Research Technician
  Fred Hutchinson Cancer Research Center
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JF

  Jerome Federspiel, MD, PhD

  Maternal Fetal Medicine Fellow in Training
  Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology
  Duke University Medical Center
  Durham, North Carolina

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• 

  Vance Fowler, Jr., MD, MHS

  Professor of Medicine
  Division of Infectious Diseases
  Duke University
  Durham, North Carolina

  Disclosure: Abbvie : Grant/Research Support (Status: Ongoing); Actavis : Grant/Research Support; Advanced Liquid Logics : Grant/Research Support; Affinergy : Consultant, Research Grant or Support; Affinium : Consultant; Allergan : Grant/Research Support; Ampliphi Biosciences : Consultant; Armata : Consultant (Status: Ongoing); Basilea : Consultant, Research Grant or Support; Bayer : Consultant, Consultant; C3J : Consultant; CARB-X : Consultant (Status: Ongoing); Cerexa : Consultant, Research Grant or Support; Contrafect : Consultant, Research Grant or Support; Cubist : Grant/Research Support; Debiopharm : Consultant; Destiny : Consultant; Durata : Consultant; Forest : Grant/Research Support; Genentech : Consultant, Research Grant or Support; ICBiome : Consultant (Status: Ongoing); Integrated Biotherapeutics : Consultant; Janssen : Consultant, Research Grant or Support; Karius : Grant/Research Support; Locus : Grant/Research Support; Medical Biosurfaces : Grant/Research Support; Medicines Co. : Consultant; Medimmune : Consultant, Research Grant or Support; Merck : Consultant, Research Grant or Support; NIH : Grant/Research Support; Novadigm : Consultant; Novartis : Consultant, Research Grant or Support; Pfizer : Grant/Research Support; Regeneron : Consultant, Research Grant or Support; Tetraphase : Consultant; Theravance : Consultant, Research Grant or Support; Valanbio : Board Member (Status: Ongoing), Other Financial or Material Support (Status: Ongoing), Stock options (Status: Ongoing); xBiotech : Consultant
• RG

  Rebecca Gardner, MD

  Associate Professor
  Department of Pediatrics / Hematology-Oncology / Center for Clinical and Translational Research
  University of Washington / Seattle Children's Hospital / Ben Towne Center for Childhood Cancer Research
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• DG

  Damian Green, MD

  Associate Professor
  Clinical Research Division
  Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington School of Medicine, Seattle, WA
  Seattle, Washington

  Disclosure: Cellectar Biosciences (Grant/Research Support)GSK (Advisor or Review Panel member)Juno Therapeutics (Grant/Research Support, Advisor or Review Panel member, Other Financial or Material Support, Royalities)Seattle Genetics (Grant/Research Support, Advisor or Review Panel member)
• AH

  Alexandra Herbers, MD PhD

  Attending Hematologist
  Medicine, Division of Hematology
  Jeroen Bosch Hospital, Zuid-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• 

  Joshua Hill, MD

  Assistant Professor
  Fred Hutchinson Cancer Research Center; University of Washington
  Seattle, Washington

  Disclosure: Allogene (Consultant)Allovir (Consultant)Gilead (Consultant)Karius (Grant/Research Support, Scientific Research Study Investigator)Takeda (Grant/Research Support, Scientific Research Study Investigator)
• AH

  Alexandre Hirayama, MD

  Dr.
  Clinical Research Division /Immunotherapy Integrated Research Center
  Fred Hutchinson Cancer Research Center, Seattle, WA
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• QH

  Quan Yao Ho, MBBS, MRCP, MMed, FAMS

  Dr
  Department of Renal Medicine
  Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JJ

  Jeroen Janssen, MD PhD

  Attending Hematologist. Equal contribution as last author
  Hematology
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JK

  Jacob Keane-Candib, n/a

  Mr.
  Vaccine and Infectious Disease Division
  Fred Hutchinson Cancer Research Center, Seattle, WA
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• TK

  Terence Kee, MBBS (Aust), MRCP (UK), FAMS, FRCP, FASN, GDipHML

  Assoc Prof
  Department of Renal Medicine
  Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• RK

  Richard Kiener, PhD

  Researcher
  University of Regensberg
  Regensberg, Bayern, Germany

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• MK

  Mark Kramer, MD PhD

  Professor and attending Internist
  Medicine
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• EK

  Elizabeth Krantz, MS

  Statistical Research Associate
  Fred Hutch Cancer Research Center
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• BL

  Birgit Lissenberg-Witte, MSc

  Statistician
  Epidemiology & Biostatistics
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JM

  Joyce Maalouf, MS, MPH

  Ms.
  Vaccine and Infectious Disease Division
  Fred Hutchinson Cancer Research Center, Seattle, WA
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• DM

  David Maloney, MD, PhD

  Professor
  Clinical Research Division / Immunotherapy Integrated Research Center / Division of Oncology
  Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington, Seattle, WA
  Seattle, Washington

  Disclosure: A2 Biotherapeutics (Consultant, Other Financial or Material Support, Stock Options)Bioline Rx (Consultant)Celgene (Consultant, Grant/Research Support)Gilead (Consultant)Juno Therapeutics (Consultant, Research Grant or Support, Other Financial or Material Support, four pending patents, not issued, licensed, no royalities, no licensees)Kite Pharma (Consultant, Grant/Research Support)Novartis (Consultant)Pharmacyclics (Consultant)
• 

  Francisco Marty, MD

  Associate Professor
  Infectious Diseases
  Brigham and Women's Hospital
  Boston, MA

  Disclosure: Allovir (Consultant)Amplyx (Consultant)Ansun (Scientific Research Study Investigator)Avir (Consultant)Cidara (Scientific Research Study Investigator)F2G (Consultant, Scientific Research Study Investigator)Kyorin (Consultant)Merck (Consultant, Grant/Research Support, Scientific Research Study Investigator)New England Journal of Medicine (Other Financial or Material Support, Honorarium for Video)Regeneron (Consultant, Scientific Research Study Investigator)ReViral (Consultant)Scynexis (Scientific Research Study Investigator)Symbio (Consultant)Takeda (Scientific Research Study Investigator)United Medical (Consultant)WHISCON (Scientific Research Study Investigator)
• MM

  Marco Mielcarek, MD

  Professor
  Medicine / Medical Oncology
  Fred Hutchinson Cancer Research Center; University of Washington
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• SM

  Seung Hyun Moon, MD, MPA

  VP
  Transplant Medicine
  AlloVir
  Cambridge, Massachusetts

  Disclosure: AlloVir (Employee, Shareholder)
• JS

  Joshua Schiffer, MD, MSc

  Associate Professor
  Fred Hutch
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JS

  Jonne Sikkens, MD PhD

  ID Fellow, Equal contribution as first author
  Medicine, Division of Infectious Diseases
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• TS

  Terry Stevens-Ayers, MSc

  Research Technician
  Fred Hutchinson Cancer Research Center; University of Washington
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• TT

  Thuan Tong Tan, MBBS

  Senior Consultant
  Infectious Diseases
  Singapore General Hospital
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JT

  Justin Taylor, PhD

  Assistant Professor
  Vaccine and Infectious Disease Division / Department of Global Health / Department of Immunology / Interdisciplinary Program in Pathobiology / Molecular & Cellular Biology Program
  Fred Hutchinson Cancer Research Center / University of Washington, Seattle, WA
  Seattle, Washington

  Disclosure: Vir Biotechnology (Grant/Research Support)
• ST

  Sobhana Thangaraju, MBBS, MRCP (UK)

  Dr
  Department of Renal Medicine
  Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• CT

  Cameron Turtle, MBBS, PhD

  Associate Professor
  Clinical Research Division
  Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington School of Medicine, Seattle, WA
  Seattle, Washington

  Disclosure: Allogene (Other Financial or Material Support, Ad hoc advisory board (last 12 months))ArsenalBio (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)AstraZeneca (Grant/Research Support, Other Financial or Material Support, Ad hoc advisory board (last 12 months))Caribou Biosciences (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Century Therapeutics (Advisor or Review Panel member)Eureka Therapeutics (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Juno Therapeutics (Grant/Research Support, Other Financial or Material Support, Patent: Licensed to Juno Therapeutics)Myeloid Therapeutics (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)Nektar Therapeutics (Grant/Research Support, Other Financial or Material Support, Ad hoc advisory board (last 12 months))PACT Pharma (Other Financial or Material Support, Ad hoc advisory board (last 12 months))Precision Biosciences (Advisor or Review Panel member, Other Financial or Material Support, Stock/options)TCR2 Therapeutics (Grant/Research Support)T-CURX (Advisor or Review Panel member)
• MV

  Michiel Van Agtmael, MD PhD

  Professor and attending ID specialist, PI Equal contribution as last author
  Medicine, division of Infectious Diseases and Pharmacotherapy
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• WV

  Wies Vasmel, MD PhD

  Attending Hematologist
  Medicine Division of Hematology
  Onze Lieve Vrouwe Gasthuis
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• RW

  Ralf Wagner, PhD

  Professor
  University of Regensberg
  Regensberg, Bayern, Germany

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• HX

  Hu Xie, MS

  Statistical Research Associate
  Fred Hutchinson Cancer Research Center; University of Washington
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• PY

  Paula Ypma, MD

  Attending Hematologist
  Hematology
  Haga Hospital
  Den Haag, Zuid-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• ZZ

  Zhiji Zhang, MS

  Statistical Analyst
  Certara
  Jersey City, New Jersey

  Disclosure: AlloVir (Independent Contractor)
• SZ

  Sonja Zweegman, MD PhD

  Professor and attending Hematologist
  Hematology
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Presenting Author(s)

• 

  Nick de Jonge, MD

  PhD candidate & Resident
  Hematology
  Amsterdam UMC
  Amsterdam, Noord-Holland, Netherlands

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio
• 

  Emily Eichenberger, MD

  Infectious Disease Fellow
  Department of Medicine
  Duke University
  Durham, North Carolina

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio
• 

  Michael Ison, MD MS

  Professor of Medicine (Infectious Diseases) and Surgery (Organ Transplantation)
  Infectious Diseases and Organ Transplantation
  Northwestern University
  Chicago, Illinois

  Disclosure: Adagio : Consultant (Status: Ongoing); AiCuris () : Grant/Research Support; AlloVir : Consultant (Status: Ongoing); Celltrion () : Consultant; Cidara : Consultant (Status: Ongoing); Genentech () : Advisor or Review Panel member, Consultant, Grant/Research Support; Janssen () : Consultant, Grant/Research Support; Merck : DSMB (Status: Ongoing), Other Financial or Material Support (Status: Ongoing); SAB Biotherapuetics : DSMB (Status: Ongoing), Other Financial or Material Support (Status: Ongoing); Sequiris : DSMB (Status: Ongoing), Other Financial or Material Support (Status: Ongoing); Shionogi () : Consultant; Shire () : Grant/Research Support; Takeda : DSMB (Status: Ongoing), Other Financial or Material Support (Status: Ongoing); Viracor () : Consultant; Vitaeris : DSMB (Status: Ongoing), Other Financial or Material Support (Status: Ongoing)

  Slides Slides and Audio
• 

  Sophie Tan, MBBS, MRCP

  Infectious Diseases Fellow
  Department of Infectious Diseases
  Singapore General Hospital, Singapore
  Singapore, Singapore

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio
• 

  Carla Walti, MD

  Dr.
  Vaccine and Infectious Disease Division
  Fred Hutchinson Cancer Research Center, Seattle, WA
  Basel, Basel-Stadt, Switzerland

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio
• 

  Danniel Zamora, MD

  Infectious Diseases Acting Instructor
  University of Washington
  Seattle, Washington

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio

Presentations:

• Combinatorial Polyfunctionality Analysis of Antigen-specific T-cell Subsets (COMPASS) as a Predictor for Clinically Significant CMV Infection in the Letermovir Era
  Danniel Zamora, MD – University of Washington; Elizabeth Duke, MD – Fred Hutch; Hu Xie, MS – Fred Hutchinson Cancer Research Center; University of Washington; Bradley Edmison, BS – Fred Hutchinson Cancer Research Center; Brenda Akoto, n/a – Fred Hutch; Richard Kiener, PhD – University of Regensberg; Terry Stevens-Ayers, MSc – Fred Hutchinson Cancer Research Center; University of Washington; Ralf Wagner, PhD – University of Regensberg; Marco Mielcarek, MD – Fred Hutchinson Cancer Research Center; University of Washington; Joshua Schiffer, MD, MSc – Fred Hutch; Stephen De Rosa, MD – Fred Hutch; Michael Boeckh, MD PhD – Fred Hutchinson Cancer Research Center
• Economic and Clinical Burden of Respiratory Virus Infections in Allogeneic Hematopoietic Cell Transplantation Recipients
  Michael G. Ison, MD MS – Northwestern University; Nelson Chao, MD – Duke; Francisco M. Marty, MD – Brigham and Women's Hospital; Seung Hyun Moon, MD, MPA – AlloVir; Zhiji Zhang, MS – Certara; Aastha Chandak, PhD – Certara
• Antibodies to Vaccine-preventable Infections After CAR-T Cell Immunotherapy for B Cell Malignancies
  Carla S. Walti, MD – Fred Hutchinson Cancer Research Center, Seattle, WA; Joyce Maalouf, MS, MPH – Fred Hutchinson Cancer Research Center, Seattle, WA; Jim Boonyaratanakornkit, MD PhD – Fred Hutchinson Cancer Research Center; Jacob Keane-Candib, n/a – Fred Hutchinson Cancer Research Center, Seattle, WA; Justin J. Taylor, PhD – Fred Hutchinson Cancer Research Center / University of Washington, Seattle, WA; Alexandre V. Hirayama, MD – Fred Hutchinson Cancer Research Center, Seattle, WA; Merav Bar, MD – Fred Hutchinson Cancer Research Center / Department of Medicine University of Washington; Rebecca A. Gardner, MD – University of Washington / Seattle Children's Hospital / Ben Towne Center for Childhood Cancer Research; Damian J. Green, MD – Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington School of Medicine, Seattle, WA; Michael Boeckh, MD PhD – Fred Hutchinson Cancer Research Center; David G. Maloney, MD, PhD – Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington, Seattle, WA; Elizabeth M. Krantz, MS – Fred Hutch Cancer Research Center; Cameron J. Turtle, MBBS, PhD – Fred Hutchinson Cancer Research Center / Seattle Care Cancer Alliance / University of Washington School of Medicine, Seattle, WA; Joshua A. Hill, MD – Fred Hutchinson Cancer Research Center; University of Washington
• Dengue Virus Infection Among Renal Transplant Recipients in Singapore: A 15-year Single Center Retrospective Review
  Sophie Tan, MBBS, MRCP – Singapore General Hospital, Singapore; Quan Yao Ho, MBBS, MRCP, MMed, FAMS – Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore; Sobhana Thangaraju, MBBS, MRCP (UK) – Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore; Thuan Tong Tan, MBBS – Singapore General Hospital; Terence Kee, MBBS (Aust), MRCP (UK), FAMS, FRCP, FASN, GDipHML – Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore; Jasmine Chung Shimin, MBBS (Hons)(Australia), MRCP (UK) – Singapore General Hospital, SingHealth Duke-NUS Transplant Centre, Singapore
• Infective Endocarditis Among Solid Organ Transplant Recipients in the United States
  Emily Eichenberger, MD – Duke University; Michael M. Dagher, MD – Duke University Medical Center; Vance G. Fowler, Jr., MD, MHS – Duke University; Jerome Federspiel, MD, PhD – Duke University Medical Center
• Short versus Extended Antibiotic Treatment with a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients with Fever of Unknown Origin: A Randomized Multicenter Noninferiority Trial
  Nick A. de Jonge, MD – Amsterdam UMC; Jonne Sikkens, MD PhD – Amsterdam UMC; Sonja Zweegman, MD PhD – Amsterdam UMC; Aart Beeker, MD PhD – Spaarne Gasthuis; Paula Ypma, MD – Haga Hospital; Alexandra Herbers, MD PhD – Jeroen Bosch Hospital; Wies Vasmel, MD PhD – Onze Lieve Vrouwe Gasthuis; Arne de Kreuk, MD PhD – Onze Lieve Vrouwe Gasthuis; Juleon Coenen, MD PhD – Isala hospital; Birgit Lissenberg-Witte, MSc – Amsterdam UMC; Andries Budding, MD PhD – Amsterdam UMC; Mark Kramer, MD PhD – Amsterdam UMC; Michiel Van Agtmael, MD PhD – Amsterdam UMC; Jeroen Janssen, MD PhD – Amsterdam UMC