O-6 - Antimicrobial insights

Co-Author(s)

• CA

  Cesar Arias, M.D., MSc, Ph.D., FIDSA

  Professor
  Internal Medicine
  CARMiG, UTHealth and Center for Infectious Diseases, UTHealth School of Public Health, HOU, TX ; Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, BOG, COL
  Houston, Texas

  Disclosure: Entasis Therapeutics : Scientific Research Study Investigator; MeMed : Scientific Research Study Investigator; Merck : Grant/Research Support
• KB

  Ken Blount, PhD

  Chief Scientific Officer
  Rebiotix, Inc.
  Roseville, Minnesota

  Disclosure: Rebiotix Inc. (Employee)
• MC

  Melissa Cruz, BS, MPH

  Research Associate
  McGovern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• AD

  Andrew Davis, BS

  Bioinformatics Scientist
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• LD

  Lalitagauri Deshpande, PhD

  Scientist
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• LD

  Lorena Diaz, Ph.D.

  Associate Professor
  Universidad El Bosque
  Bogota, Cundinamarca, Colombia

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• AD

  An Dinh, BS

  Research Engineer
  Internal Medicine, Infectious Disease
  Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• TD

  Timothy Doyle

  Lead Molecular Scientist
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: Allergan (Research Grant or Support)Allergan (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support)
• SE

  Samuel Erickson, BS

  Medical Student
  McGovern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• NF

  Nicky Ferdyan, BS

  Sr. Research Associate
  Ferring Research Institute
  San Diego, California

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• BF

  Bryan Fuchs, PhD

  Research Therapeutic Area Head - Gastroenterology and Hepatology
  Ferring Research Institute
  San Diego, California

  Disclosure: Ferring Pharmaceuticals (Employee)
• DG

  Danielle Garsin, Ph.D.

  Professor
  McGovern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• CG

  Carlos Gonzalez, MS

  Statistician
  BioRankings, LLC
  St. Louis, Missouri

  Disclosure: BioRankings, LLC (Employee)
• 

  Ayesha Khan, PhD

  Postdoctoral Fellow in Infectious Diseases
  Center for Antimicrobial Resistance and Microbial Genomics (CARMiG)
  UTHealth
  Houston, TX

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• SK

  Sarah Klein, BA

  Associate Scientist II
  Rebiotix, Inc.
  Roseville, Minnesota

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• JL

  Jill Lindley

  Drug Development Specialist
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: Allergan (Research Grant or Support)Qpex Biopharma (Research Grant or Support)
• 

  Rodrigo Mendes, PhD

  Director
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Basilea Pharmaceutica International, Ltd (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Department of Health and Human Services (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Pfizer (Research Grant or Support)
• BM

  Barbara Murray, M.D.

  Professor and Division Director
  Infectious Diseases, Department of Internal Medicine
  Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• OO

  Oscar Ortega-Recalde, MD, MSc, PhD

  Assistant Professor
  Molecular Genetics and Antimicrobial Resistance Unit
  Universidad El Bosque
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• DP

  Diana Panesso-Botero, PhD

  Assistant Professor
  UTHSC at Houston Mc Govern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• CP

  Cedric Pettaway, Jr., BS

  Research Assistant
  McGovern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• SQ

  Steve Qi, PhD

  Director, ADME
  DMPK
  Ferring Research Institute
  San Diego, California

  Disclosure: Ferring Pharmaceuticals (Employee)
• JR

  Jinnethe Reyes, MSc, PhD

  Postdoctoral fellow
  Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• MR

  Maria Reyes, n/a

  Research Assistant
  UTHSC at Houston Mc Govern Medical School
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• SR

  Sandra Rincon, PhD

  Professor
  Molecular Genetics and Antimicrobial Resistance Unit
  Universidad el Bosque
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• RR

  Rafael Rios, MSc

  Assistant Professor
  Molecular Genetics and Antimicrobial Resistance Unit
  Universidad El Bosque
  Bogota, Distrito Capital de Bogota, Colombia

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• BR

  Brieanna Roth, n/a

  Microbiologist III
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: Allergan (Research Grant or Support)
• 

  Helio Sader, MD, PhD, FIDSA

  Senior Director
  JMI Laboratories
  North Liberty, Iowa

  Disclosure: A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Melinta (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support)
• BS

  Bill Shannon, PhD MBA

  Founder and Managing Partner
  BioRankings, LLC
  St. Louis, Missouri

  Disclosure: BioRankings, LLC (Employee)
• KS

  Kavindra Singh, Ph.D.

  Professor
  Department of Internal Medicine
  Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
• KS

  Karthik Srinivasan, PhD

  Vice President, DMPK
  Ferring Pharmaceuticals
  San Diego, California

  Disclosure: Ferring Pharmaceuticals (Employee)
• 

  Dana Walsh, PhD

  Scientist
  Rebiotix, Inc.
  Roseville, MN

  Disclosure: Rebiotix Inc. (Employee)

Presenting Author(s)

• 

  Mariana Castanheira, PhD

  Chief Scientific Officer
  JMI Laboratories
  North Liberty, IA

  Disclosure: 1928 Diagnostics (Research Grant or Support)A. Menarini Industrie Farmaceutiche Riunite S.R.L. (Research Grant or Support)Allergan (Research Grant or Support)Allergan (Research Grant or Support)Amplyx Pharmaceuticals (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cidara Therapeutics (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Cipla Ltd. (Research Grant or Support)Fox Chase Chemical Diversity Center (Research Grant or Support)GlaxoSmithKline (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Melinta Therapeutics, Inc. (Research Grant or Support)Merck (Research Grant or Support)Merck (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Merck & Co, Inc. (Research Grant or Support)Paratek Pharma, LLC (Research Grant or Support)Pfizer (Research Grant or Support)Qpex Biopharma (Research Grant or Support)

  Slides Slides and Audio
• 

  Sara Gomez-Villegas, MD

  Post Doctoral Research Fellow
  University of Texas Health Sciences Center at houston
  Houston, Texas

  Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

  Slides Slides and Audio
• 

  William Miller, MD

  Assistant Professor
  UTHealth McGovern Medical School
  Houston, Texas

  Disclosure: Entasis () : Grant/Research Support; Merck () : Grant/Research Support; Shionogi () : Advisory Board

  Slides Slides and Audio
• 

  Romeo Papazyan, PhD

  Scientist
  Ferring Research Institute
  San Diego, CA

  Disclosure: Ferring Pharmaceuticals: Employee

  Slides Slides and Audio
• 

  Dana Walsh, PhD

  Scientist
  Rebiotix, Inc.
  Roseville, MN

  Disclosure: Rebiotix Inc. (Employee)

  Slides Slides and Audio

Presentations:

• Update on Prevalence Of mcr-like Genes Among enterobacterales in a Global Surveillance Program: Decline in Occurrence of mcr-1.1 and Emergence of mcr-9.1 and mcr-10.1
  Lalitagauri M. Deshpande, PhD – JMI Laboratories; Andrew P. Davis, BS – JMI Laboratories; Rodrigo E. Mendes, PhD – JMI Laboratories; Mariana Castanheira, PhD – JMI Laboratories
• in Vitro selection Of enterobacter Cloacae with Cefepime, Meropenem, and Ceftazidime-avibactam Generate Diverse Resistance Mechanism
  Mariana Castanheira, PhD – JMI Laboratories; Jill Lindley – JMI Laboratories; Brieanna Roth, n/a – JMI Laboratories; Timothy B. Doyle – JMI Laboratories; Andrew P. Davis, BS – JMI Laboratories; Helio S. Sader, MD, PhD, FIDSA – JMI Laboratories
• The Membrane Antimicrobial Peptide Defense (MadRS) System Orchestrates Resistance Against Antibiotics and Host Innate Immune Peptides in enterococcus Faecalis
  William R. Miller, MD – UTHealth McGovern Medical School; Ayesha Khan, PhD – UTHealth; Samuel G. Erickson, BS – McGovern Medical School; Cedric H. Pettaway, Jr., BS – McGovern Medical School; Rafael Rios, MSc – Universidad El Bosque; Melissa R. Cruz, BS, MPH – McGovern Medical School; An Q. Dinh, BS – Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,; Lorena Diaz, Ph.D. – Universidad El Bosque; Danielle A. Garsin, Ph.D. – McGovern Medical School; Cesar A. Arias, M.D., MSc, Ph.D., FIDSA – CARMiG, UTHealth and Center for Infectious Diseases, UTHealth School of Public Health, HOU, TX ; Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, BOG, COL
• regulation of the Staphylococcal β-lactamase Plays a Major Role in the cefazolin Inoculum Effect
  Sara I. Gomez-Villegas, MD – University of Texas Health Sciences Center at houston; An Q. Dinh, BS – Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,; Jinnethe Reyes, MSc, PhD – Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia; Diana Panesso-Botero, PhD – UTHSC at Houston Mc Govern Medical School; Maria I. Reyes, n/a – UTHSC at Houston Mc Govern Medical School; Rafael Rios, MSc – Universidad El Bosque; Oscar Ortega-Recalde, MD, MSc, PhD – Universidad El Bosque; Lorena Diaz, Ph.D. – Universidad El Bosque; Sandra Rincon, PhD – Universidad el Bosque; Barbara E. Murray, M.D. – Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,; Kavindra V. Singh, Ph.D. – Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, Houston, TX,; Cesar A. Arias, M.D., MSc, Ph.D., FIDSA – CARMiG, UTHealth and Center for Infectious Diseases, UTHealth School of Public Health, HOU, TX ; Molecular Genetics and Antimicrobial Resistance Unit and International Center for Microbial Genomics, Universidad El Bosque, BOG, COL
• Rapid Restoration of Bile Acid Compositions After Treatment with Investigational Microbiota-based Therapeutic RBX2660 for Recurrent clostrioides Difficile Infection
  Nicky Ferdyan, BS – Ferring Research Institute; Romeo Papazyan, PhD – Ferring Research Institute; Dana M. Walsh, PhD – Rebiotix, Inc.; Sarah Klein, BA – Rebiotix, Inc.; Steve Qi, PhD – Ferring Research Institute; Ken Blount, PhD – Rebiotix, Inc.; Karthik Srinivasan, PhD – Ferring Pharmaceuticals; Bryan Fuchs, PhD – Ferring Research Institute
• Antimicrobial Resistance Genes Are Reduced Following Administration of Investigational Microbiota-based Therapeutic RBX7455 to Individuals with Recurrent clostrioides Difficile Infection
  Dana M. Walsh, PhD – Rebiotix, Inc.; Carlos Gonzalez, MS – BioRankings, LLC; Bill Shannon, PhD MBA – BioRankings, LLC; Ken Blount, PhD – Rebiotix, Inc.