718 - Asymptomatic campylobacteriosis as a risk factor for developing acute neurological syndromes in Veracruz, Mexico

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Presenting Author(s)

Luis Del Carpio-Orantes

Researcher
Grupo de Estudio para el Diagnóstico y Tratamiento de COVID-19 en Veracruz, México
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Co-Author(s)

JS

Jesús Salvador Sánchez-Díaz

Dr
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
KP

Karla Gabriela Peniche Moguel

Dr
Instituto Mexicano del Seguro Social
veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MP

Miguel Arnulfo Perfecto-Arroyo

Dr
Instituto Mexicano del Seguro Social
veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
IS

Ishar Solis-Sánchez

Dr
Instituto Mexicano del Seguro Social
veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
SG

Sergio García-Méndez

Dr
Hospital Regional de Alta Especialidad de Oaxaca
Oaxaca, Oaxaca, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MM

Maria del Pilar Mata-Miranda

Dr
Instituto Mexicano del Seguro Social
veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MP

María del Rosario Pola-Ramírez

Miss María del Rosario Pola Ramírez
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
EC

Edna Rosario Contreras-Sánchez

Dr
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
RL

Rosa Isela Luna-Ceballos

Dra Rosa Isela Luna-Ceballos
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
CC

Celso Ossiel Contreras-Sánchez

Dr Celso Ossiel Contreras-Sánchez
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
JG

Juan Antonio Gutiérrez-Moreno

Dr Juan Antonio Gutiérrez Moreno
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
NM

Nancy Patricia Moreno-Aldama

Dr
Instituto Mexicano del Seguro Social
veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AG

América Alejandrina González-Arce

Dra América Alejandrina González-Arce
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
CD

Claudia Leticia Dorantes-Nava

Dra Claudia Leticia Dorantes Nava
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AM

Alvaro Efren Munguia-Sereno

Dr Alvaro Efren Munguia-Sereno
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
ZG

Zeltzin Olivia Guerrero-Mancinas

Dra Zeltzin Olivia Guerrero-Mancinas
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
EA

Elisa Estefanía Aparicio-Sánchez

Dra Elisa Estefanía Aparicio-Sánchez
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
OG

Omar García-Hernández

Dr Omar García Hernández
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
OS

Orlando Israel Segura-Rodríguez

Dr Orlando Israel Segura-Rodríguez
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AE

Alejandro Escobar-Huerta

Dr Alejandro Escobar-Huerta
Instituto Mexicano del Seguro Social
Veracruz, Veracruz-Llave, Mexico
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Background: Campylobacter infection is the main cause of diarrheal disease, however it is recognized as a risk factor for developing Guillain Barré syndrome, which has been previously corroborated in our population after analyzing the incidence of the syndrome during arboviral outbreaks of 2016-2018, resulting that 75% of the cases were due to infection by Campylobacter. Furthermore, of these patients, 83% did not present gastrointestinal symptoms, constituting an asymptomatic campylobacteriosis at the intestinal level, and Guillain Barré syndrome could be its primary manifestation. Reason why the need arose to look in this population for cases of asymptomatic campylobacteriosis.

Methods: Analytical, observational and prospective study. 200 healthy and asymptomatic individuals over 18 years of age were selected in the Veracruz Norte branch of the Mexican Institute of Social Security during September to December 2019, who were asked for a stool sample, which was subjected to a study to search for Campylobacter through a chromatographic immunoassay test for the qualitative detection of said bacteria (Certest). Patients who were positive to the Certest test underwent stool culture (Campy-bap) in order to typify the identified Campylobacter species.

Results: In the search for Campilobacter, the Certest was positive in 6 (3.0%); In 5 (83.3%) subjects some variety of Campylobacter could be isolated by stool culture, in 4 (66.7%) Campylobacter Jejuni was isolated and in 1 (16.7%) Campylobacter Coli was isolated. The positive result of Certest was similar between women and men [4 (3.8%) women vs 2 (2.1%) men; p = 0.684)]. However, in relation to the culture, there was the percentage of women in whom the culture was positive for Campilobacter Jejuní was statistically significant [4 (100%) VS 0 (0.0%); p = 0.038].Characteristics of the study population.

Positive cases of campylobacter

Positive cases by Certest and Campy-bap

Conclusion: Asymptomatic positive cases of Campilobacter were identified in this study population in 3%, mainly isolating Campilobacter jejuni, which leads to the conclusion that there are cases of asymptomatic Campylobacteriosis that could act as a risk factor for the development of acute neurological syndromes related to the presence of the bacteria