Category: COVID-19 Complications, Co-infections, and Clinical Outcomes

Poster Session: COVID-19 Complications, Co-infections, and Clinical Outcomes

401 - Short Term Outcomes in Multisystem Inflammatory Syndrome in Children (MIS-C) Related to COVID-19

The ePoster content is available to users who are logged in.<br><br>Please log in and then come back here to use this button.

Presenting Author(s)

Mariawy Riollano-Cruz

Clinical Third Year Fellow Pediatric Infectious Diseases
Icahn School of Medicine at Mount Sinai Hospital
Astoria, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Co-Author(s)

CM

Christina L. Marshall

Medical Student
Icahn School of Medicine at Mount Sinai
New York, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
sk

shanna kowalsky

Associate Pediatric Hospital Epidemiologist, Assistant Professor Pediatric Infectious Diseases
Mount Sinai Hospital
New York, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
MT

Michael Tosi

Professor of Pediatrics
Icahn School of Medicine at Mount Sinai
New York, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
RP

Roberto Posada

Associate Professor
Icahn School of Medicine at Mount SInai
New York, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
RT

Rebecca Trachtman

Assistant Professor of Pediatrics
Icahn School of Medicine at Mount Sinai
New York, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
AP

Alberto Paniz-Mondolfi

ASSISTANT PROFESSOR
Icahn School of Medicine at Mount Sinai
NY, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.
ES

Emilia Mia. Sordillo

ASSOCIATE PROFESSOR
The Mount Sinai Hospital Mount Sinai Morningside and Mount Sinai West
NY, New York
Disclosure: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Background:

MIS-C is a multi-system inflammatory syndrome which has been described in pediatric patients after COVID-19 since late April. Our objective is to describe the short-term outcomes of the first 15 cases with MIS-C, who presented for care to a tertiary pediatric referral center.

Methods: This is a retrospective chart review of patients who met MIS-C criteria based on the New York State Department of Health case definition and who were admitted to the Mount Sinai Hospital in New York City, between April 24 and May 14, 2020. We collected clinical and laboratory data during their hospital admission and subsequent outpatient follow up.

Results: The range of the length of hospital stay was 6-13 days (mean=7 days). One patient expired on day 9 of hospitalization. At the time of discharge, all patients had normalization of inflammatory markers. All patients were discharged on anticoagulation therapy for 14 days. One patient was readmitted with a subdural hematoma at day 13 post discharge and 3 patients had bruising at their follow up visit 7-12 days after hospital discharge. All patients had normalization of cardiac enzymes prior to hospital discharge. Abnormalities in coronary arteries and cardiac function which were observed during hospitalizations in 4 (27%) and 8 (53%) patients respectively, had resolved by day 6-35 post discharge (mean=20 days).

Conclusion: Although patients with MIS-C can present with severe multi-organ involvement and shock, the majority of the patients in our experience had resolution of symptoms and normalization of laboratory parameters within a few weeks of initial symptoms. Our findings underscore the need to carefully weigh the risk and benefits of anticoagulation therapy and to monitor this treatment closely. Further research is needed to determine long-term outcomes of these patients.